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Overcoming barriers to early disease intervention

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Fig. 1: Differences in primary prevention, secondary prevention and early disease intervention, depicting target groups, goals and examples for each approach.
Fig. 2: Hypothetical illustrative example of integrated early disease intervention paradigm.


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Our perspective has benefited from a global network of colleagues. In particular, it has been challenged, informed and enriched by conversations with many people, including R. Hendricks, D. Blumenthal, B. Wiegand, K. Wildenhaus, J. Hedrick, S. Brady, G. Pigino, J. M. Peyrin, P. Prieto, J. Fleming and A. Zarur.

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Correspondence to H. Hugo Caicedo.

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D.A.H. consults for Johnson & Johnson, Verily Life Sciences, and Worrell. He has received research support from Olympus. A.P. is on the Advisory Boards of Pear Therapeutics. G.P.P. consults for Johnson & Johnson, Takeda, Bristol-Myers Squibb, Eli Lilly and Tolero, and serves on the Board of Directors of Axcella Health and Celixir.

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Caicedo, H.H., Hashimoto, D.A., Caicedo, J.C. et al. Overcoming barriers to early disease intervention. Nat Biotechnol 38, 669–673 (2020).

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