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Cancer-eating immune cells kitted out with CARs

Nature Biotechnology volume 38, pages 509–511 (2020)Cite this article

Immunotherapy startups look to engineer macrophages to fight solid tumors.

But hot on Carisma’s heels are Thunder Biotech and Myeloid Therapeutics, each with similar CAR-based cellular therapies — all centered around the common theme of harnessing the Pacman-like ability of macrophages or other myeloid-lineage cells to eat away at cancer tissue — in earlier stages of preclinical development. All three companies are banking on the idea that CAR-expressing phagocytes will finally deliver on the promise of adoptive cell immunotherapy for solid tumors, something that CAR-T cells and all other gene-modified lymphocytes — be they γδ T cells, natural killer T cells or natural killer cells — have so far failed to do.

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  1. Somerville, MA, USA

    Elie Dolgin

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  1. Elie Dolgin
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Dolgin, E. Cancer-eating immune cells kitted out with CARs. Nat Biotechnol 38, 509–511 (2020). https://doi.org/10.1038/s41587-020-0520-5

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