Taxonomic composition of healthy adult stool sample A, which was subjected to bead beating followed by nanopore sequencing vs. short read sequencing; and which was also subjected to the high molecular weight extraction and nanopore sequencing. Only one of the ten additional healthy adult stool samples that were bead beaten yielded sufficient quantities of SPRI size-selected DNA for subsequent nanopore sequencing. All other samples yielded short fragments by TapeStation quantification (Supplementary Fig. 8). The ten most abundant taxa are depicted in this figure for clarity of representation.