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Increased cyber-biosecurity for DNA synthesis

Nature Biotechnology volume 38, pages 1379–1381 (2020)Cite this article

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To the Editor — Commercial DNA synthesizers sell billions of nucleotides to customers each year, amounting to hundreds of millions of dollars in sales1. As DNA synthesis becomes more widespread, concern is mounting that a cyberattack intervening with synthetic DNA orders could lead to the synthesis of nucleic acids encoding parts of pathogenic organisms or harmful proteins and toxins. Reassuringly, such an attack is non-trivial. Most DNA synthesis providers check each requested sequence across databases of problematic sequences before order fulfillment, as per the 2010 US Health and Human Services guidelines2. Unfortunately, however, there are no comprehensive databases of pathogenic sequences, and the guidelines — unenforced outside of US National Institutes of Health (NIH) grantees3 — are outdated.

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Fig. 1: Malicious DNA injection performed by a remote cyber-criminal.

References

  1. Berry, D. J. Hist. Technol. 35, 374–404 (2019).

    Article  Google Scholar 

  2. U. S. Department of Health Human Services. Screening framework guidance for providers of synthetic double-stranded DNA. https://www.phe.gov/Preparedness/legal/guidance/syndna/Pages/default.aspx (2010).

  3. US National Institutes of Health. NIH guidelines for research involving recombinant or synthetic nucleic acid molecules. https://osp.od.nih.gov/wp-content/uploads/2019_NIH_Guidelines.htm (2019).

  4. World Economic Forum. Biosecurity innovation and risk reduction: a global framework for accessible, safe and secure DNA synthesis. https://www.weforum.org/reports/biosecurity-innovation-and-risk-reduction-a-global-framework-for-accessible-safe-and-secure-dna-synthesis-582d582cd4 (2020).

  5. IASB. The IASB code of conduct for best practices in gene synthesis. http://op.bna.com.s3.amazonaws.com/hl.nsf/r%3FOpen%3Djaqo-7xqpnr (2009).

  6. Harmonized screening protocol, I.G.S. v2.0. https://genesynthesisconsortium.org/wp-content/uploads/IGSCHarmonizedProtocol11-21-17.pdf (2017).

  7. Murch, R. & DiEuliis, D. Front. Bioeng. Biotechnol. 7, 235 (2019).

  8. Cui, Y., Xu, J., Cheng, M., Liao, X. & Peng, S. Interdiscip. Sci. 10, 455–465 (2018).

    Article  CAS  Google Scholar 

  9. Wang, L. et al. Sci. Rep. 5, 17517 (2015).

    Article  CAS  Google Scholar 

  10. Scarfone, K. & Mell, P. Guide to intrusion detection and prevention systems (IDPS). NIST Special Publication 800-94 Rev. 1 (draft) (National Institute of Standards and Technology, 2012).

  11. Kwon, D. et al. A survey of deep learning-based network anomaly detection. Cluster Comput. 22, 949–961 (2019).

    Article  Google Scholar 

  12. Ahmed, M., Mahmood, A. N. & Hu, J. J. Netw. Comput. Appl. 60, 19–31 (2016).

    Article  Google Scholar 

  13. Adam, L. et al. Nat. Biotechnol. 29, 208–210 (2011).

    Article  CAS  Google Scholar 

  14. Tucker, J. B. Issues Sci. Technol. 26, 23–32 (2010).

    Google Scholar 

  15. Raisaro, J.L. et al. MedCo: enabling privacy-conscious exploration of distributed clinical and genomic data. in 4th International Workshop on Genome Privacy and Security (GenoPri’17) (2017).

  16. West, R. & Gronvall, G. K. Nat. Biotechnol. 38, 1021 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Software and Information Systems Engineering, Ben-Gurion University of the Negev, Be’er Sheva, Israel

    Rami Puzis & Yuval Elovici

  2. Cyber Security Research Center, Ben-Gurion University of the Negev, Be’er Sheva, Israel

    Rami Puzis, Dor Farbiash, Oleg Brodt & Yuval Elovici

  3. Jusidman Science Center for Youth, Ben-Gurion University of the Negev, Be’er Sheva, Israel

    Dor Farbiash

  4. Telekom Innovation Labs, Ben-Gurion University of the Negev, Be’er Sheva, Israel

    Oleg Brodt

  5. Zvi Meitar Institute for Legal Implications of Emerging Technologies, IDC Herzliya, Herzliya, Israel

    Dov Greenbaum

  6. Harry Radzyner School of Law, IDC Herzliya, Herzliya, Israel

    Dov Greenbaum

  7. Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA

    Dov Greenbaum

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  1. Rami Puzis
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  2. Dor Farbiash
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  3. Oleg Brodt
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  4. Yuval Elovici
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  5. Dov Greenbaum
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Correspondence to Dov Greenbaum.

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The authors declare no competing interests.

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Puzis, R., Farbiash, D., Brodt, O. et al. Increased cyber-biosecurity for DNA synthesis. Nat Biotechnol 38, 1379–1381 (2020). https://doi.org/10.1038/s41587-020-00761-y

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