Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Patents
  • Published:

PATENTS

Emerging patent landscape for non-viral vectors used for gene therapy

Nature Biotechnology volume 38, pages 151–157 (2020)Cite this article

Subjects

An analysis of the emerging patent landscape of gene therapies under development, focusing on non-viral vectors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: An overview of the publications and patents related to the term ‘gene therapy’.
Fig. 2: Current trends in the development of emerging gene therapy products.
Fig. 3: Patenting trends in the technology field of non-viral vectors.
Fig. 4: Direction of technology and investment trends analyses.
Fig. 5: Cell diagram representing the most prevalent keywords from the patents belonging to the top organizations in the technology field.

References

  1. Raper, S. E. et al. Mol. Genet. Metab. 80, 148–158 (2003).

    Article  CAS  Google Scholar 

  2. Kim, T. K. & Eberwine, J. H. Anal. Bioanal. Chem. 397, 3821–3826 (2010).

    Google Scholar 

  3. Garçon, L. et al. Blood 122, 912–921 (2013).

    Article  Google Scholar 

  4. de Sousa Russo-Carbolante, E. M. et al. Biotechnol. Lett. 33, 23–31 (2010).

    Article  Google Scholar 

  5. Michieletto, D., Lusic, M., Marenduzzo, D. & Orlandini, E. Nat. Commun. 10, 575 (2019).

    Article  CAS  Google Scholar 

  6. Atianand, M. K. & Fitzgerald, K. A. J. Immunol. 190, 1911–1918 (2013).

    Article  CAS  Google Scholar 

  7. Tao, J., Zhou, X. & Jiang, Z. IUBMB Life 68, 858–870 (2016).

    Article  CAS  Google Scholar 

  8. Gándara, C., Affleck, V. & Stoll, E. A. Hum. Gene Ther. Methods https://doi.org/10.1089/hgtb.2017.098 (published online 1 February 2018).

    Article  Google Scholar 

  9. Jenke, A. C. W. et al. Proc. Natl. Acad. Sci. USA 101, 11322–11327 (2004).

    Article  CAS  Google Scholar 

  10. Stavrou, E. F. et al. Sci. Rep. 7, 40673 (2017).

    Article  CAS  Google Scholar 

  11. Hagedorn, C., Antoniou, M. N. & Lipps, H. J. Mol. Ther. Nucleic Acids 3, e118 (2013).

    Article  Google Scholar 

  12. Saunders, F., Sweeney, B., Antoniou, M. N., Stephens, P. & Cain, K. PLoS One 10, (e0120096 (2015).

    Google Scholar 

  13. Haase, R. et al. BMC Biotechnol. 10, 20 (2010).

    Article  Google Scholar 

Download references

Acknowledgements

We acknowledge support from the Basic Medical Sciences Department at the Purdue University School of Veterinary Medicine, Purdue Center for Cancer Research, and the Purdue Institute for Drug Discovery. This work was supported in part by NIH grants R01CA196947 and R01AR069079 and FAPESP grants 2017/25364-6, 2013/08135-2 and 2014/22500-8.

Author information

Authors and Affiliations

  1. Department of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA

    Virginia Picanço-Castro & Marxa Leão Figueiredo

  2. Center for Cell-based Therapy (CTC), Regional Blood Center of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    Virginia Picanço-Castro & Dimas Tadeu Covas

  3. Strategic Partnerships and Business Development Office, Instituto Butantan, São Paulo, Brazil

    Cristiano Gonçalves Pereira & Dimas Tadeu Covas

  4. School of Economics, Business Administration and Accounting, University of São Paulo, São Paulo, Brazil

    Cristiano Gonçalves Pereira & Geciane Silveira Porto

  5. Institute of Advanced Studies of the University of São Paulo, São Paulo, Brazil

    Geciane Silveira Porto

  6. Department of General Biology, Medical School, University of Patras, Patras, Greece

    Aglaia Athanassiadou

  7. Purdue Institute for Drug Discovery & Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, USA

    Marxa Leão Figueiredo

Authors
  1. Virginia Picanço-Castro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cristiano Gonçalves Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dimas Tadeu Covas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Geciane Silveira Porto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Aglaia Athanassiadou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marxa Leão Figueiredo
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

V.P.C., C.G.P., G.S.P. and M.L.F. designed the experiments, analyzed the data and wrote the manuscript; A.A. and D.C. discussed the data and wrote the manuscript.

Corresponding authors

Correspondence to Virginia Picanço-Castro or Marxa Leão Figueiredo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Picanço-Castro, V., Pereira, C.G., Covas, D.T. et al. Emerging patent landscape for non-viral vectors used for gene therapy. Nat Biotechnol 38, 151–157 (2020). https://doi.org/10.1038/s41587-019-0402-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-019-0402-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research