Emerging patent landscape for non-viral vectors used for gene therapy

An analysis of the emerging patent landscape of gene therapies under development, focusing on non-viral vectors.

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Fig. 1: An overview of the publications and patents related to the term ‘gene therapy’.
Fig. 2: Current trends in the development of emerging gene therapy products.
Fig. 3: Patenting trends in the technology field of non-viral vectors.
Fig. 4: Direction of technology and investment trends analyses.
Fig. 5: Cell diagram representing the most prevalent keywords from the patents belonging to the top organizations in the technology field.


  1. 1.

    Raper, S. E. et al. Mol. Genet. Metab. 80, 148–158 (2003).

  2. 2.

    Kim, T. K. & Eberwine, J. H. Anal. Bioanal. Chem. 397, 3821–3826 (2010).

  3. 3.

    Garçon, L. et al. Blood 122, 912–921 (2013).

  4. 4.

    de Sousa Russo-Carbolante, E. M. et al. Biotechnol. Lett. 33, 23–31 (2010).

  5. 5.

    Michieletto, D., Lusic, M., Marenduzzo, D. & Orlandini, E. Nat. Commun. 10, 575 (2019).

  6. 6.

    Atianand, M. K. & Fitzgerald, K. A. J. Immunol. 190, 1911–1918 (2013).

  7. 7.

    Tao, J., Zhou, X. & Jiang, Z. IUBMB Life 68, 858–870 (2016).

  8. 8.

    Gándara, C., Affleck, V. & Stoll, E. A. Hum. Gene Ther. Methods (published online 1 February 2018).

  9. 9.

    Jenke, A. C. W. et al. Proc. Natl. Acad. Sci. USA 101, 11322–11327 (2004).

  10. 10.

    Stavrou, E. F. et al. Sci. Rep. 7, 40673 (2017).

  11. 11.

    Hagedorn, C., Antoniou, M. N. & Lipps, H. J. Mol. Ther. Nucleic Acids 3, e118 (2013).

  12. 12.

    Saunders, F., Sweeney, B., Antoniou, M. N., Stephens, P. & Cain, K. PLoS One 10, (e0120096 (2015).

  13. 13.

    Haase, R. et al. BMC Biotechnol. 10, 20 (2010).

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We acknowledge support from the Basic Medical Sciences Department at the Purdue University School of Veterinary Medicine, Purdue Center for Cancer Research, and the Purdue Institute for Drug Discovery. This work was supported in part by NIH grants R01CA196947 and R01AR069079 and FAPESP grants 2017/25364-6, 2013/08135-2 and 2014/22500-8.

Author information

V.P.C., C.G.P., G.S.P. and M.L.F. designed the experiments, analyzed the data and wrote the manuscript; A.A. and D.C. discussed the data and wrote the manuscript.

Correspondence to Virginia Picanço-Castro or Marxa Leão Figueiredo.

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The authors declare no competing interests.

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Picanço-Castro, V., Pereira, C.G., Covas, D.T. et al. Emerging patent landscape for non-viral vectors used for gene therapy. Nat Biotechnol 38, 151–157 (2020).

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