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BUILDING A BUSINESS

The biotech living and the walking dead

A detailed look at the economic impact of university-licensed life science startups across the United States reveals vast differences in the effectiveness of different regions to create ventures and sustain them as viable entities.

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Fig. 1

Libby Thomas

Fig. 2: Final disposition of selected ULS firms, by cohort.

Libby Thomas

Fig. 3

Libby Thomas

Fig. 4: Average number of employees, by category and cohort.

Libby Thomas

Fig. 5

Libby Thomas

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. 1.

    National Science Foundation. Higher Education Research and Development Survey, 2018 https://www.nsf.gov/statistics/srvyherd/#tabs-2 (accessed 5 July 2019).

  2. 2.

    Valdivia, W.D. University start-ups: critical for improving technology transfer. (Brookings, 2013).

  3. 3.

    Rubens, A., Spigarelli, F., Cavicchi, A. & Rinaldi, C. J. Enterprising Communities People Places Glob. Econ. 11, 354–372 (2017).

    Article  Google Scholar 

  4. 4.

    Kotha, R., Crama, P. & Kim, P. H. Acad. Manag. J. 61, 1307–1342 (2018).

    Article  Google Scholar 

  5. 5.

    Moore, G. & Davis, K. in Building high-tech clusters: Silicon Valley and beyond (eds. Bresnahan, T. F. & Gambardella, A.) 7–39 (Cambridge Univ. Press, 2004).

  6. 6.

    Folta, T. B., Cooper, A. C. & Baik, Y. J. Bus. Venturing 21, 217–242 (2006).

    Article  Google Scholar 

  7. 7.

    Pe’er, A. & Keil, T. J. Bus. Venturing. 28, 354–372 (2013).

    Article  Google Scholar 

  8. 8.

    Meyer, J. W. & Rowan, B. Am. J. Sociol. 83, 340–363 (1977).

    Article  Google Scholar 

  9. 9.

    Leonard, W. University of Utah, MIT lead nation in new companies founded. The Deseret News https://www.deseretnews.com/article/700009951/University-of-Utah-MIT-lead-nation-in-new-companies-founded.html (16 February 2010; July 2019).

  10. 10.

    Maffly, B. Fits and startups: is U. tech transfer flawed? The Salt Lake Tribune https://archive.sltrib.com/article.php?id=51619785&itype=cmsid (16 May 2011; accessed 5 July 2019).

  11. 11.

    TEConomy Partners. The economic impact of the U. S. biopharmaceutical industry: national and state estimates http://phrma-docs.phrma.org/sites/default/files/pdf/biopharmaceuticaul-industry-economic-impact.pdf (2016; accessed 5 July 2019).

  12. 12.

    Social Security Administration. National average wage index https://www.ssa.gov/oact/cola/AWI.html (accessed 5 July 2019).

  13. 13.

    Booth, B. & Salehizadeh, B. Nat. Biotechnol. 29, 579–583 (2011).

    CAS  Article  Google Scholar 

  14. 14.

    Jacobs, J. The Economy of Cities (Vintage Books, 1969).

  15. 15.

    Jacobs, J. The Nature of Economies (Vintage Books, 2000).

  16. 16.

    Feldman, M. P. & Audretsch, D. B. Eur. Econ. Rev. 43, 409–429 (1999).

    Article  Google Scholar 

  17. 17.

    Lerner, J. Boulevard of Broken Dreams: Why Public Efforts to Boost Entrepreneurship and Venture Capital Have Failed and What to Do about It (Princeton Univ. Press, 2009).

  18. 18.

    McCann, B. T. & Folta, T. B. J. Bus. Venturing 26, 104–123 (2011).

    Article  Google Scholar 

  19. 19.

    Ivkovic, Z. & Weisbrenner, S. J. Finance 60, 267–306 (2005).

    Article  Google Scholar 

  20. 20.

    Kerr, S. Acad. Manag. J. 18, 769–783 (1975).

    CAS  Google Scholar 

  21. 21.

    Roberts, A. Where Brandeis got “sunlight is the best disinfectant.” https://aroberts.us/2015/03/01/where-brandeis-got-sunlight-is-the-best-disinfectant/ (2015, accessed 5 July 2019).

  22. 22.

    Powers, J. B. & McDougall, P. P. J. Bus. Ventur. 20, 291–311 (2005).

    Article  Google Scholar 

  23. 23.

    Flanigan, J. If it’s eye care technology, this must be Orange County. The New York Times https://www.nytimes.com/2008/05/15/business/smallbusiness/15edge.html (15 May 2008; accessed 5 July 2019).

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Acknowledgements

We thank the Kaufmann Foundation for their generous financial support of this research.

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Correspondence to Paul C. Godfrey.

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Godfrey, P.C., Allen, G.N. & Benson, D. The biotech living and the walking dead. Nat Biotechnol 38, 132–141 (2020). https://doi.org/10.1038/s41587-019-0399-1

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