BUILDING A BUSINESS

The biotech living and the walking dead

A detailed look at the economic impact of university-licensed life science startups across the United States reveals vast differences in the effectiveness of different regions to create ventures and sustain them as viable entities.

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Fig. 1

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Fig. 2: Final disposition of selected ULS firms, by cohort.

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Fig. 3

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Fig. 4: Average number of employees, by category and cohort.

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Fig. 5

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. 1.

    National Science Foundation. Higher Education Research and Development Survey, 2018 https://www.nsf.gov/statistics/srvyherd/#tabs-2 (accessed 5 July 2019).

  2. 2.

    Valdivia, W.D. University start-ups: critical for improving technology transfer. (Brookings, 2013).

  3. 3.

    Rubens, A., Spigarelli, F., Cavicchi, A. & Rinaldi, C. J. Enterprising Communities People Places Glob. Econ. 11, 354–372 (2017).

  4. 4.

    Kotha, R., Crama, P. & Kim, P. H. Acad. Manag. J. 61, 1307–1342 (2018).

  5. 5.

    Moore, G. & Davis, K. in Building high-tech clusters: Silicon Valley and beyond (eds. Bresnahan, T. F. & Gambardella, A.) 7–39 (Cambridge Univ. Press, 2004).

  6. 6.

    Folta, T. B., Cooper, A. C. & Baik, Y. J. Bus. Venturing 21, 217–242 (2006).

  7. 7.

    Pe’er, A. & Keil, T. J. Bus. Venturing. 28, 354–372 (2013).

  8. 8.

    Meyer, J. W. & Rowan, B. Am. J. Sociol. 83, 340–363 (1977).

  9. 9.

    Leonard, W. University of Utah, MIT lead nation in new companies founded. The Deseret News https://www.deseretnews.com/article/700009951/University-of-Utah-MIT-lead-nation-in-new-companies-founded.html (16 February 2010; July 2019).

  10. 10.

    Maffly, B. Fits and startups: is U. tech transfer flawed? The Salt Lake Tribune https://archive.sltrib.com/article.php?id=51619785&itype=cmsid (16 May 2011; accessed 5 July 2019).

  11. 11.

    TEConomy Partners. The economic impact of the U. S. biopharmaceutical industry: national and state estimates http://phrma-docs.phrma.org/sites/default/files/pdf/biopharmaceuticaul-industry-economic-impact.pdf (2016; accessed 5 July 2019).

  12. 12.

    Social Security Administration. National average wage index https://www.ssa.gov/oact/cola/AWI.html (accessed 5 July 2019).

  13. 13.

    Booth, B. & Salehizadeh, B. Nat. Biotechnol. 29, 579–583 (2011).

  14. 14.

    Jacobs, J. The Economy of Cities (Vintage Books, 1969).

  15. 15.

    Jacobs, J. The Nature of Economies (Vintage Books, 2000).

  16. 16.

    Feldman, M. P. & Audretsch, D. B. Eur. Econ. Rev. 43, 409–429 (1999).

  17. 17.

    Lerner, J. Boulevard of Broken Dreams: Why Public Efforts to Boost Entrepreneurship and Venture Capital Have Failed and What to Do about It (Princeton Univ. Press, 2009).

  18. 18.

    McCann, B. T. & Folta, T. B. J. Bus. Venturing 26, 104–123 (2011).

  19. 19.

    Ivkovic, Z. & Weisbrenner, S. J. Finance 60, 267–306 (2005).

  20. 20.

    Kerr, S. Acad. Manag. J. 18, 769–783 (1975).

  21. 21.

    Roberts, A. Where Brandeis got “sunlight is the best disinfectant.” https://aroberts.us/2015/03/01/where-brandeis-got-sunlight-is-the-best-disinfectant/ (2015, accessed 5 July 2019).

  22. 22.

    Powers, J. B. & McDougall, P. P. J. Bus. Ventur. 20, 291–311 (2005).

  23. 23.

    Flanigan, J. If it’s eye care technology, this must be Orange County. The New York Times https://www.nytimes.com/2008/05/15/business/smallbusiness/15edge.html (15 May 2008; accessed 5 July 2019).

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Acknowledgements

We thank the Kaufmann Foundation for their generous financial support of this research.

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Correspondence to Paul C. Godfrey.

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The authors declare no competing interests.

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Godfrey, P.C., Allen, G.N. & Benson, D. The biotech living and the walking dead. Nat Biotechnol 38, 132–141 (2020). https://doi.org/10.1038/s41587-019-0399-1

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