Number of phosphosites in PDTs matched that were present in PhosphoSitePlus for the same kinase as a function of tuning the EBDT algorithm with different probability thresholds (a) or site-kinase inhibition ratio thresholds (b). (c) Number of phosphosites found to be PDTs of given kinases as a function of number of compounds in kinase inhibitors fingerprints for the respective kinase. Total number of PDTs in dataset is 6,206. Boxplots show median, interquartile ranges, and ranges. Outliers are shown as individual data points.