Supplementary Figure 1: MuTect2 has high sensitivity in detecting mosaics. | Nature Biotechnology

Supplementary Figure 1: MuTect2 has high sensitivity in detecting mosaics.

From: Accurate detection of mosaic variants in sequencing data without matched controls

Supplementary Figure 1

(a) MuTect2 detected more simulated mutations than GATK-HC-p2, GATK-HC-p5 and MosaicHunter at different allele fractions and read depths in non-RepeatMasker regions. Variants with >0.4 VAF were excluded from the call sets shown. (b) MuTect2 detected more real mosaics than the other tools considered, as confirmed by single cell sequencing from three individuals (1465, 4638 and 4643). These include both RepeatMasker and non-RepeaMasker region sites.

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