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Emerging technologies for improved deep brain stimulation

Nature Biotechnology volume 37, pages 1024–1033 (2019)Cite this article

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A Publisher Correction to this article was published on 09 September 2019

This article has been updated

Abstract

Deep brain stimulation (DBS) is an effective treatment for common movement disorders and has been used to modulate neural activity through delivery of electrical stimulation to key brain structures. The long-term efficacy of stimulation in treating disorders, such as Parkinson’s disease and essential tremor, has encouraged its application to a wide range of neurological and psychiatric conditions. Nevertheless, adoption of DBS remains limited, even in Parkinson’s disease. Recent failed clinical trials of DBS in major depression, and modest treatment outcomes in dementia and epilepsy, are spurring further development. These improvements focus on interaction with disease circuits through complementary, spatially and temporally specific approaches. Spatial specificity is promoted by the use of segmented electrodes and field steering, and temporal specificity involves the delivery of patterned stimulation, mostly controlled through disease-related feedback. Underpinning these developments are new insights into brain structure–function relationships and aberrant circuit dynamics, including new methods with which to assess and refine the clinical effects of stimulation.

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Fig. 1: Deep brain stimulation.
Fig. 2: Field steering.
Fig. 3: A comparison of different stimulation strategies.

Change history

  • 09 September 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Acknowledgements

This work was supported by the Medical Research Council UK (MC_UU_12024/1 1188 to P.B. and MR/R020418/1 to H.C.). T.D. is supported by the Royal Academy of Engineering through a chair in emerging technology. C.M. is supported by NIH R01 NS086100.

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Authors and Affiliations

  1. MRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK

    Hayriye Cagnan, Timothy Denison & Peter Brown

  2. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

    Hayriye Cagnan, Timothy Denison & Peter Brown

  3. Department of Engineering Sciences, University of Oxford, Oxford, UK

    Timothy Denison

  4. School of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Cameron McIntyre

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  1. Hayriye Cagnan
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  2. Timothy Denison
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Correspondence to Hayriye Cagnan.

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Competing interests

C.M. is a shareholder in Surgical Information Sciences, Hologram Consultants, Cortics, Autonomic Technologies, Cardionomic and Enspire DBS, as well as a paid consultant to Boston Scientific Neuromodulation. C.M. has intellectual property directly related to the areas we discuss and receives royalties from Neuros Medical, Boston Scientific, Hologram Consultants and Qr8 Health. T.D. is a shareholder in Medtronic, is a consultant for Inspire Medical and Cortec Neurotechnologies, is an advisor for Nia therapeutics, and has intellectual property directly related to the areas we discuss. P.B. has intellectual property directly related to the areas we discuss. H.C. has intellectual property directly related to the areas we discuss.

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Cagnan, H., Denison, T., McIntyre, C. et al. Emerging technologies for improved deep brain stimulation. Nat Biotechnol 37, 1024–1033 (2019). https://doi.org/10.1038/s41587-019-0244-6

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