Supplementary Figure 5: The structures and dose-response curves for the generated molecules. | Nature Biotechnology

Supplementary Figure 5: The structures and dose-response curves for the generated molecules.

From: Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Supplementary Figure 5

(a) Six generated compounds were tested in a dose-dependent manner against DDR1 tyrosine kinase. Compounds 1 and 2 demonstrated the IC50 values in the low nanomolar range. (b) Compounds 2 and 4 were additionally rescreened towards DDR1 kinase using another biochemical assay (Thermo Fisher-PR6913A) and have demonstrated the IC50 values of 37.12 and 155.6 nM respectively (below). Measure of center is mean, error bars are s.d. (n=2 for each experiment).

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