Supplementary Figure 9: Effects of compounds 1 and 2 on cellular fibrosis markers collagen I, α-actin and CCN2 (normalized to GAPDH) in LX-2 cells. | Nature Biotechnology

Supplementary Figure 9: Effects of compounds 1 and 2 on cellular fibrosis markers collagen I, α-actin and CCN2 (normalized to GAPDH) in LX-2 cells.

From: Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Supplementary Figure 9

Representative blots of produced collagen I, α-actin and CCN2 in LX-2 cells treated with TGF-b in the presence of DDR1 inhibitors at different doses. SB25334 was served as a positive control. SB25334 and compound 1 suppressed collagen I production in a dose dependent manner. SB25334 inhibited α-actin production at the dose of 10 μM. Experiments were repeated at least once and similar results were obtained.

Back to article page