Supplementary Figure 8: Effects of compounds 1 and 2 on cellular fibrosis markers α-actin and CCN2 (normalized to GAPDH) in MRC-5 cells. | Nature Biotechnology

Supplementary Figure 8: Effects of compounds 1 and 2 on cellular fibrosis markers α-actin and CCN2 (normalized to GAPDH) in MRC-5 cells.

From: Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Supplementary Figure 8

Representative blots of produced α-actin and CCN2 in MRC-5 cells treated with TGF-b in the presence of DDR1 inhibitors at different doses. SB25334 and dasatinib were served as a positive control. Dasatinib and compound 1 suppressed α-actin and CCN2 production at the concentration of 10 μM. SB25334 inhibited α-actin production at the dose of 10 μM. Experiments were repeated at least once and similar results were obtained.

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