(a) Tissue adenylate triphosphate (ATP) and adenylate monophosphate (AMP) ratio. The symbols of the dot plot overlay correspond to the unique independent biological replicates (n = 3 throughout the figure) and match between Figs. 2 and 3; Supplementary Figs. 2, 4 and 5; and Supplementary Table 2. (b) Tissue adenylate triphosphate (ATP) and adenylate diphosphate (ADP) ratio. (c) Oxygen uptake. (d) Plasma urea concentrations. (e) Lactate clearance derived from in and outflow measurements. (f) Plasma potassium concentrations. Error bars: mean ± SEM.