Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GENE EDITING

Jumping at the chance for precise DNA integration

CRISPR–Cas-associated transposases enable targeted integration of new sequences into genomes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: From CRISPR–Cas to CRISPR–transposase systems.

References

  1. Pickar-Oliver, A. & Gersbach, C.A. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-019-0131-5 (2019).

    Article  CAS  Google Scholar 

  2. Strecker, J. et al. Science 365, 48–53 (2019).

    Article  CAS  Google Scholar 

  3. Klompe, S.E., Vo, P.L.H., Halpin-Healy, T.S. & Sternberg, S.H. Nature https://doi.org/10.1038/s41586-019-1323-z (2019).

    Article  Google Scholar 

  4. Deyle, D. R. & Russell, D. W. Curr. Opin. Mol. Ther. 11, 442–447 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Gaj, T., Sirk, S. J. & Barbas, C. F.3rd. Biotechnol. Bioeng. 111, 1–15 (2014).

    Article  CAS  Google Scholar 

  6. Mills, R. E. et al. Trends Genet. 23, 183–191 (2007).

    Article  CAS  Google Scholar 

  7. Peters, J. E., Makarova, K. S., Shmakov, S. & Koonin, E. V. Proc. Natl Acad. Sci. USA 114, E7358–E7366 (2017).

    Article  CAS  Google Scholar 

  8. Gaj, T., Gersbach, C. A. & Barbas, C. F. 3rd Trends Biotechnol. 7, 397–405 (2013).

    Article  Google Scholar 

  9. Kosicki, M., Tomberg, K. & Bradley, A. Nat. Biotechnol. 36, 765–771 (2018).

    Article  CAS  Google Scholar 

  10. Schiroli, G. et al. Cell Stem Cell 24, 551–565 (2019).

    Article  CAS  Google Scholar 

  11. Nelson, C. E. et al. Nat. Med. 25, 427–432 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Charles A. Gersbach.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kwon, J.B., Gersbach, C.A. Jumping at the chance for precise DNA integration. Nat Biotechnol 37, 1004–1006 (2019). https://doi.org/10.1038/s41587-019-0210-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-019-0210-3

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research