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ANTISENSE OLIGONUCLEOTIDES

Mind the gap!

A simple chemical modification can substantially reduce the toxicity of antisense oligonucleotides.

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Acknowledgements

A.M.K. thanks J. Watts for comments.

Author information

Competing interests

A.M.K. is a founder, employee and shareholder of Checkmate Pharma.

Correspondence to Arthur M. Krieg.

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Fig. 1: Common ASO designs.