A simple chemical modification can substantially reduce the toxicity of antisense oligonucleotides.
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A.M.K. thanks J. Watts for comments.
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A.M.K. is a founder, employee and shareholder of Checkmate Pharma.
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Krieg, A.M. Mind the gap!. Nat Biotechnol 37, 622–623 (2019). https://doi.org/10.1038/s41587-019-0141-z
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DOI: https://doi.org/10.1038/s41587-019-0141-z