Nature Biotechnology’s academic spinouts of 2018

Our annual survey highlights startups taking on gene therapy, adoptive immune cell therapy, gene editing, and drugs targeting RNA modifications and the unfolded protein response. Ken Garber, Esther Landhuis, Melanie Senior, Cormac Sheridan and Laura DeFrancesco report.

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References

  1. 1.

    Zinn, E. et al. Cell Rep. 12, 1056–1068 (2015).

  2. 2.

    Suzuki, J. et al. Sci. Rep. 7, 45524 (2017).

  3. 3.

    Pan, B. et al. Nat. Biotechnol. 35, 264–272 (2017).

  4. 4.

    Shearer, A. E. & Smith, R. J. Otolaryngol. Head Neck Surg. 153, 175–182 (2015).

  5. 5.

    Pan, B. et al. Neuron 99, 736–753.e6 (2018).

  6. 6.

    Jones, D. Nat. Biotechnol. 36, 1128–1129 (2018).

  7. 7.

    Cho, J. H., Collins, J. J. & Wong, W. W. Cell 173, 1426–1438.e11 (2018).

  8. 8.

    Klichinsky, M. et al. in Proceedings of the American Association for Cancer Research Annual Meeting 2017 Vol. 77, 4575 (2017), https://doi.org/10.1158/1538-7445.AM2017-4575

  9. 9.

    Ritchie, D. et al. Cancer Immunol. Immunother. 56, 155–163 (2007).

  10. 10.

    Ellebrecht, C. T. et al. Science 353, 179–184 (2016).

  11. 11.

    Liou, H. C., Boothby, M. R. & Glimcher, L. H. Science 242, 69–71 (1988).

  12. 12.

    Cubillos-Ruiz, J. et al. Cell 161, 1527–1538 (2015).

  13. 13.

    Song, M. et al. Nature 562, 423–428 (2018).

  14. 14.

    Chen, X. et al. Nature 508, 103–107 (2014).

  15. 15.

    Perry, R. P., Kelley, D. E., Friderici, K. & Rottman, F. Cell 4, 387–394 (1975).

  16. 16.

    Meyer, K. D. et al. Cell 149, 1635–1646 (2012).

  17. 17.

    Dominissini, D. et al. Nature 485, 201–206 (2012).

  18. 18.

    Geula, S. et al. Science 347, 1002–1006 (2015).

  19. 19.

    Vu, L. P. et al. Nat. Med. 23, 1369–1376 (2017).

  20. 20.

    Barbieri, I. et al. Nature 552, 126–131 (2017).

  21. 21.

    Lyko, F. Nat. Rev. Genet. 19, 81–92 (2018).

  22. 22.

    Li, Z. et al. Cancer Cell 31, 127–141 (2017).

  23. 23.

    Zhang, S. et al. Cancer Cell 31, 591–606.e6 (2017).

  24. 24.

    Zhang, C. et al. Proc. Natl Acad. Sci. USA 113, E2047–E2056 (2016).

  25. 25.

    Dominissini, D. et al. Nature 530, 441–446 (2016).

  26. 26.

    Safra, M. et al. Nature 551, 251–255 (2017).

  27. 27.

    Li, X. et al. Mol. Cell 68, 993–1005 (2017).

  28. 28.

    Carlson, D. F. et al. Nat. Biotechnol. 34, 479–481 (2016).

  29. 29.

    Lampreht Tratar, U., Horvat, S. & Cemazar, M. Front. Oncol. 8, 268 (2018).

  30. 30.

    Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Nature 533, 420–424 (2016).

  31. 31.

    Gaudelli, N. M. et al. Nature 551, 464–471 (2017).

  32. 32.

    Kim, Y. B. et al. Nat. Biotechnol. 35, 371–376 (2017).

  33. 33.

    Hu, J. H. et al. Nature 556, 57–63 (2018).

  34. 34.

    Huang, T.P. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0134-y (2019).

  35. 35.

    Zuo, E. et al. Science 364, 289–292 (2019).

  36. 36.

    Jin, S. et al. Science 364, 292–295 (2019).

  37. 37.

    Grünewald, J. et al. Nature https://doi.org/10.1038/s41586-019-1161-z (2019).

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