Supplementary Fig. 3: Indel frequencies for CP1300-CBEmax and CP1300-ABEmax at five genomic sites. | Nature Biotechnology

Supplementary Fig. 3: Indel frequencies for CP1300-CBEmax and CP1300-ABEmax at five genomic sites.

From: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Supplementary Fig. 3

(a) Percent of all sequencing reads containing an indel following modification by CP-CBEmax variants compared to CBEmax at five genomic sites containing a variety of adenines and cytosines in HEK293T cells. (b) Percent of all sequencing reads containing an indel following modification by CP-ABEmax variants compared to ABEmax at five genomic sites containing a variety of adenines and cytosines in HEK293T cells. Values and error bars reflect the mean ± s.d. of three independent biological replicates performed by different researchers on different days.

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