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Nature Biotechnologyvolume 37pages520522 (2019) | Download Citation

In vivo studies indicate that cytosine but not adenine base editors induce elevated levels of genome-wide off-target substitutions.

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Author information


  1. School of Life Science and Technology, ShanghaiTech University, Shanghai, China

    • Jia Chen
  2. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China

    • Bei Yang
  3. CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    • Li Yang


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The authors declare no competing financial interests.

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