Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ORGANOIDS

Polarizing brain organoids

Human brain organoids are endowed with regional topography using engineered signaling centers.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Assembly of polarized human brain organoids from human pluripotent stem cells.

References

  1. Pașca, S. P. Nature 553, 437–445 (2018).

    Article  Google Scholar 

  2. Cederquist, G. Y. et al. Nat. Biotechnol.. https://doi.org/10.1038/s41587-019-0085-3 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M. & Sestan, N. Neuron 89, 248–268 (2016).

    Article  CAS  Google Scholar 

  4. Kiecker, C. & Lumsden, A. Annu. Rev. Neurosci. 35, 347–367 (2012).

    Article  CAS  Google Scholar 

  5. Ericson, J. et al. Cell 81, 747–756 (1995).

    Article  CAS  Google Scholar 

  6. Lupo, G., Harris, W. A. & Lewis, K. E. Nat. Rev. Neurosci. 7, 103–114 (2006).

    Article  CAS  Google Scholar 

  7. Birey, F. et al. Nature 545, 54–59 (2017).

    Article  CAS  Google Scholar 

  8. Blassberg, R., Macrae, J. I., Briscoe, J. & Jacob, J. Hum. Mol. Genet. 25, 693–705 (2016).

    Article  CAS  Google Scholar 

  9. Sakaguchi, H. et al. Nat. Commun. 6, 8896 (2015).

    Article  CAS  Google Scholar 

  10. Jo, J. et al. Cell Stem Cell 19, 248–257 (2016).

    Article  CAS  Google Scholar 

  11. Martyn, I., Kanno, T. Y., Ruzo, A., Siggia, E. D. & Brivanlou, A. H. Nature 558, 132–135 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sergiu P. Pașca.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miura, Y., Pașca, S.P. Polarizing brain organoids. Nat Biotechnol 37, 377–378 (2019). https://doi.org/10.1038/s41587-019-0084-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-019-0084-4

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research