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MICROSCOPY

Brain maps at the nanoscale

Large brain tissue sections are imaged with nanoscale resolution using expansion and lattice light sheet microscopy.

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Fig. 1: Combination of expansion microscopy with lattice light sheet microscopy enables brain-wide imaging with nanoscale resolution.

References

  1. Gao, R. et al. Science https://doi.org/10.1126/science.aau8302 (2019).

  2. Denk, W. & Horstmann, H. PLoS Biol. 2, e329 (2004).

    Article  Google Scholar 

  3. Hell, S. W. & Wichmann, J. Opt. Lett. 19, 780–782 (1994).

    Article  CAS  Google Scholar 

  4. Rust, M. J., Bates, M. & Zhuang, X. Nat. Methods 3, 793–795 (2006).

    Article  CAS  Google Scholar 

  5. Betzig, E. et al. Science 313, 1642–1645 (2006).

    Article  CAS  Google Scholar 

  6. Hess, S. T., Girirajan, T. P. & Mason, M. D. Biophys. J. 91, 4258–4272 (2006).

    Article  CAS  Google Scholar 

  7. Wei, L. et al. Nature 544, 465–470 (2017).

    Article  CAS  Google Scholar 

  8. Chen, F., Tillberg, P. W. & Boyden, E. S. Science 347, 543–548 (2015).

    Article  CAS  Google Scholar 

  9. Wassie, A. T., Zhao, Y. & Boyden, E. S. Nat. Methods 16, 33–41 (2019).

    Article  CAS  Google Scholar 

  10. Chen, B. C. et al. Science 346, 1257998 (2014).

    Article  Google Scholar 

  11. Yang, W. & Yuste, R. Nat. Methods 14, 349–359 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Weijian Yang or Rafael Yuste.

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Yang, W., Yuste, R. Brain maps at the nanoscale. Nat Biotechnol 37, 378–380 (2019). https://doi.org/10.1038/s41587-019-0078-2

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