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The new liver epidemic

Nature Biotechnologyvolume 37pages209214 (2019) | Download Citation

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NASH has replaced hepatitis C as the most important nonalcoholic liver disease. Biotech and pharma are racing to tap into this enormous market.

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References

  1. 1.

    Perry, R. J., Samuel, V. T., Petersen, K. F. & Shulman, G. I. Nature 510, 84–91 (2014).

  2. 2.

    Sanyal, A. J. et al. N. Engl. J. Med. 362, 1675–1685 (2010).

  3. 3.

    Huang, M. A. et al. Am. J. Gastroenterol. 100, 1072–1081 (2005).

  4. 4.

    Promrat, K. et al. Hepatology 51, 121–129 (2010).

  5. 5.

    Parks, D. J. et al. Science 284, 1365–1368 (1999).

  6. 6.

    Holt, J. A. et al. Genes Dev. 17, 1581–1591 (2003).

  7. 7.

    Neuschwander-Tetri, B. A. et al. Lancet 385, 956–965 (2015).

  8. 8.

    Loomba, R. et al. Hepatology 67, 549–559 (2018).

  9. 9.

    Pawlak, M. et al. Hepatology 60, 1593–1606 (2014).

  10. 10.

    Ratziu, V. et al. Gastroenterology 150, 1147–1159 (2016).

  11. 11.

    Friedman, S. L. et al. Hepatology 67, 1754–1767 (2018).

  12. 12.

    Armstrong, M. J. et al. Lancet 387, 679–690 (2016).

  13. 13.

    Patel, K. et al. Hepatology 68 (Suppl. 1), 438A, abstract 736 (2018).

  14. 14.

    Luo, J. et al. Sci. Transl. Med. 6, 247ra100 (2014).

  15. 15.

    Harrison, S. A. et al. Lancet 391, 1174–1185 (2018).

  16. 16.

    Romeo, S. et al. Nat. Genet. 40, 1461–1465 (2008).

  17. 17.

    Yuan, X. et al. Am. J. Hum. Genet. 83, 520–528 (2008).

  18. 18.

    Linden D. et al. Hepatology 68 (Supp. 1), 440A, abstract 740 (2018).

  19. 19.

    Kozlitina, J. et al. Nat. Genet. 46, 352–356 (2014).

  20. 20.

    Abul-Husn, N. S. et al. N. Engl. J. Med. 378, 1096–1106 (2018).

  21. 21.

    Ma, Y. et al. Hepatology https://doi.org/10.1002/hep.30350 (2018).

  22. 22.

    About, F., Abel, L. & Cobat, A. N. Engl. J. Med. 379, 1875–1876 (2018).

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  1. Ken Garber is a freelance reporter based in Ann Arbor, Michigan, USA

    • Ken Garber

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https://doi.org/10.1038/s41587-019-0047-9

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