Supplementary Figure 8: Enrichment in read depth with focused probe sets. | Nature Biotechnology

Supplementary Figure 8: Enrichment in read depth with focused probe sets.

From: Capturing sequence diversity in metagenomes with comprehensive and scalable probe design

Supplementary Figure 8

(a) Distribution of the enrichment in read depth, across viral genomes, provided by capture with VWAFR. Each curve represents a viral genome. At each position across a genome, the post-capture read depth is divided by the pre-capture depth, and the plotted curve is the empirical cumulative distribution of the log of these fold-change values. (b) Distribution of the enrichment in read depth, across viral genomes, provided by VWAFR over VALL. At each position across a genome, the read depth following capture with VWAFR is divided by the depth following capture with VALL, and the plotted curve is the empirical cumulative distribution of the log of these fold-change values. (c) Same as (a), but for the two-virus probe sets VMM and VZC. The mumps curves (green) show enrichment provided by VMM against pre-capture, and the Zika curves (purple) show enrichment provided by VZC against pre-capture. (d) Same as (b), but for the two-virus probe sets VMM and VZC. The mumps curves (green) show enrichment provided by VMM against VALL, and the Zika curves (purple) show enrichment provided by VZC against VALL.

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