Fig. 1: SARS-CoV-2 infection elicits durable serum anti-S antibody titres. | Nature

Fig. 1: SARS-CoV-2 infection elicits durable serum anti-S antibody titres.

From: SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Fig. 1

a, Study design. Seventy-seven convalescent individuals who had experienced mild SARS-CoV-2 infections (aged 21–69 years) were enrolled and blood was collected approximately 1 month, 4 months, 7 months and 11 months after the onset of symptoms. Bone marrow aspirates were collected from 18 of the convalescent individuals 7 to 8 months after infection and from 11 healthy volunteers (aged 23–60 years) with no history of SARS-CoV-2 infection. Follow-up bone marrow aspirates were collected from 5 of the 18 convalescent donors and 1 additional convalescent donor approximately 11 months after infection. b, Blood IgG titres against SARS-CoV-2 S (left) and influenza virus vaccine (right) measured by enzyme-linked immunosorbent assay (ELISA) in convalescent individuals (white circles) at the indicated time after onset of symptoms, and in control individuals (black circles). The dotted lines indicate the limit of detection (LOD). Mean titres and pairwise differences at each time point were estimated using a linear mixed model analysis.

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