Extended Data Fig. 5: Off-target indel formation associated with ABE8e-NRCH conversion of HBBS to HBBG Makassar in SCD CD34+ HSPCs. | Nature

Extended Data Fig. 5: Off-target indel formation associated with ABE8e-NRCH conversion of HBBS to HBBG Makassar in SCD CD34+ HSPCs.

From: Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Extended Data Fig. 5

Bar graph showing the percentage of sequencing reads containing alleles harbouring indels at on- and off-target sites in genomic DNA samples from patient CD34+ HSPCs treated with ABE8e-NRCH mRNA, protein, or untreated controls (n = 4). Data shown as mean ± s.d.

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