Extended Data Fig. 4: Structural explanations on how critical mutations affect monoclonal antibody activity. | Nature

Extended Data Fig. 4: Structural explanations on how critical mutations affect monoclonal antibody activity.

From: Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Extended Data Fig. 4

a, E484 forms hydrogen bonds with monoclonal antibodies that target the RBM. E484K causes not only steric clashes but also a charge change at antibody-binding sites, and thus abolishes binding by these RBM-directed monoclonal antibodies. Steric clashes are shown by red plates. b, Mutations at or near the NTD antigenic supersite—comprising loops N1, N3 and N5—that is recognized by many potent NTD-directed monoclonal antibodies.

Back to article page