Extended Data Fig. 10: Controls for NPY injection into PVT. | Nature

Extended Data Fig. 10: Controls for NPY injection into PVT.

From: Hunger enhances food-odour attraction through a neuropeptide Y spotlight

Extended Data Fig. 10

a, Schematic depicting injection site (top) and preference indices for experiments in Fig. 3h, i. n = 10 male mice and 10 female mice, data are mean + s.e.m. b, Post-test food consumption (Food 1) for mice in Fig. 3h, i. n = 3 male mice and 3 female mice, data are mean ± s.e.m., triangles represent individual mice. *P < 0.05, two-tailed Mann–Whitney U-test (P NPY versus control: 0.015; P NPY5R agonist versus control, 0.04). c, Fasted Npy-KO mice were injected with low NPY levels (0.02 mg kg−1) in the dorsal third ventricle, and after 15 min behaviour was analysed in the two-choice odour preference assay. n = 6 (3 male mice and 3 female mice), data are mean ± s.e.m., lines with triangles represent individual mice. P > 0.99, two-tailed Wilcoxon test. d, Fasted Npy-KO mice were injected with high NPY levels (0.2 mg kg−1) in the ventral third ventricle, and after 60 min behaviour was analysed in the two-choice odour preference assay. n = 20 (10 male mice and 10 female mice), data are mean ± s.e.m., lines with triangles represent individual mice. ***P < 0.001, two-tailed Wilcoxon test. Brain schematics are based on published brain section images31.

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