Fig. 4: Cancer immunity triggered by blockage of TGF-β signalling in CD4+ T cells is dependent on IL-4 but not on IFN-γ. | Nature

Fig. 4: Cancer immunity triggered by blockage of TGF-β signalling in CD4+ T cells is dependent on IL-4 but not on IFN-γ.

From: TGF-β suppresses type 2 immunity to cancer

Fig. 4

a, Representative flow cytometry plots and statistical analyses of IL-4 and IFN-γ expression in CD4+FOXP3 T cells from the tumour-draining lymph nodes of 23-week-old Tgfbr2fl/fl PyMT (WT; n = 8) and Thpok-cre;Tgfbr2fl/fl PyMT (KO; n = 8) mice. Data are mean ± s.e.m. (biologically independent mice). Two-tailed unpaired t-test. b, Tumour size in Ifng−/−Tgfbr2fl/fl PyMT (Ifng−/−; n = 5), Ifng−/−Thpok-cre;Tgfbr2fl/fl PyMT (Ifng−/− KO; n = 7), Il4/Tgfbr2fl/fl PyMT (Il4/; n = 5) and Il4−/−Thpok-cre;Tgfbr2fl/fl PyMT (Il4/ KO; n = 6) mice. Dashed lines indicate tumour burden from individual mice and solid lines indicate mean of tumour burden from all mice in a group. ****P < 0.0001.

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