Fig. 1: Blockage of TGF-β signalling in CD4+ T cells suppresses tumour development independently of CD8+ T cells. | Nature

Fig. 1: Blockage of TGF-β signalling in CD4+ T cells suppresses tumour development independently of CD8+ T cells.

From: TGF-β suppresses type 2 immunity to cancer

Fig. 1

a, Tumour burden in Tgfbr2fl/fl PyMT (n = 8) and Cd8a-cre;Tgfbr2fl/fl PyMT (n = 7) mice. Two-tailed unpaired t-test. b, Tumour burden in Tgfbr2fl/fl PyMT (n = 7), Thpok-cre;Tgfbr2fl/fl PyMT (n = 6), Cd8a/Tgfbr2fl/fl PyMT (n = 5), Cd8a/Thpok-cre;Tgfbr2fl/fl PyMT (n = 6) and Foxp3-cre;Tgfbr2fl/fl PyMT (n = 5) mice. Two-tailed unpaired t-test. Dashed lines indicate total tumour burden from individual mice and solid lines indicate mean of total tumour burden from all mice in a group. ****P < 0.0001; NS, not significant.

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