a, Schematic outline of the LCMV infection analysis. b, Comparison of the changes in gene expression after LCMV infection (day 8) to the epigenetic potential observed under homeostatic conditions (day 0), using a threshold of zero for differential gene expression (left) or a variable threshold analogous to a receiver operating characteristic curve (centre). The area under the curve is interpreted as a measure of the predictiveness of the epigenetic potential for LCMV-induced gene activation, plotted together with the percentage of upregulated genes that carry unrealized epigenetic potential (right). c, Enrichment of immune-related gene sets among the LCMV-induced genes (two-sided Fisher’s exact test with multiple-testing correction). Sample size (all panels): n = 3 independent biological replicates.