Extended Data Fig. 6: Analysis of transcription regulation in structural cells. | Nature

Extended Data Fig. 6: Analysis of transcription regulation in structural cells.

From: Structural cells are key regulators of organ-specific immune responses

Extended Data Fig. 6

a, Multidimensional scaling analysis of the similarity of chromatin profiles across cell types, organs and replicates based on ATAC-seq (top) and H3K4me2 ChIPmentation (bottom). b, Correlation of chromatin profiles across cell types and organs for ATAC-seq (left) and H3K4me2 ChIPmentation (right). c, Transcriptional regulators of the inferred gene-regulatory network for structural cells, arranged by similarity using multidimensional scaling. d, Motif enrichment for transcriptional regulators among differential chromatin peaks, shown separately for each regulator (one-sided hypergeometric test with multiple-testing correction). e, Gene expression of the transcriptional regulators across cell types and organs (genes discussed in the text are in bold). Sample size (all panels): n = 2 independent biological replicates.

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