Extended Data Fig. 7: Molecular binding simulations of the interaction of the S proteins of four closely related SARS-related coronaviruses with the ACE2 proteins of humans, civets and pangolins. | Nature

Extended Data Fig. 7: Molecular binding simulations of the interaction of the S proteins of four closely related SARS-related coronaviruses with the ACE2 proteins of humans, civets and pangolins.

From: Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Extended Data Fig. 7

a, Free energy (kcal mol−1) for the binding of the RBD of S proteins of four SARS-related coronaviruses to the ACE2 of potential hosts. b, Alignment of the RBD sequences (key amino acids involved in interactions with ACE2 are boxed) of the S proteins from several genetically related SARS-related coronaviruses. c, Alignment of partial ACE2 amino acid sequences (key amino acids involved in interactions with RBD are marked with arrowheads) from humans, pangolins and civets at their interface with the RBD of S proteins.

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