Fig. 1: Pathological changes in the lungs of pangolins that are potentially induced by pangolin-CoV. | Nature

Fig. 1: Pathological changes in the lungs of pangolins that are potentially induced by pangolin-CoV.

From: Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Fig. 1

ad, Histological changes in the lung tissues are compared between a virus-negative Malayan pangolin (a) and three Malayan pangolins naturally infected with pangolin-CoV (bd) (original magnification × 1,000). Proliferation and desquamation of alveolar epithelial cells and haemosiderin pigments are seen in tissues from all three infected pangolins and severe capillary congestion is seen in one of them (c). e, Viral particles are seen in double-membrane vesicles in the transmission electron microscopy image taken from Vero E6 cell culture inoculated with supernatant of homogenized lung tissue from one pangolin, with morphology indicative of coronavirus (inserts at the top right corner of e). Scale bar, 200 nm.

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