Extended Data Fig. 8: PPIs between TiP proteins and uniformly expressed proteins likely adapt basic cellular processes to mediate cellular context-specific functions. | Nature

Extended Data Fig. 8: PPIs between TiP proteins and uniformly expressed proteins likely adapt basic cellular processes to mediate cellular context-specific functions.

From: A reference map of the human binary protein interactome

Extended Data Fig. 8

a, TiP protein coverage by CCSB PPI networks for increasing levels of tissue-preferential expression. Shaded error bars are proportional to standard error of proportion, n ≥ 233 genes. b, Spearman correlation coefficients and 95% confidence intervals for correlations between degree or betweenness and tissue specificity for HuRI and Lit-BM (n = 6,684 and 4,971 proteins). c, Fraction of HuRI and Lit-BM that involve TiP proteins compared to fraction of genome that are TiP genes for increasing levels of tissue-preferential expression. d, Number of PPIs in HuRI, involving proteins in GTEx, in which both proteins are expressed in the same tissue, and the mean of the tissue-specific subnetworks. Error bar denotes s.d. e, Test for enrichment of TiP–TiP PPIs (left) and significance of average shortest path between TiP proteins (middle) in each tissue subnetwork, number of TiP proteins in each subnetwork, interacting with other TiP proteins, being part of keratin (KRT) or late-cornified envelope (LCE) protein family (right). f, g, Transcript expression levels across the BLUEPRINT haematopoietic cell lineage (f) and GTEx tissue panel (g) for three candidate genes predicted to function in apoptosis. EG, oesophagus gastroesophageal. h, Histogram of number of untransfected cells and their time of death (left) without (top) and with (bottom) addition of TRAIL. Time of death of cells expressing OTUD6A–GFP fusions versus OTUD6A expression measured as fluorescence (right) without (top) and with (bottom) addition of TRAIL. i, Apoptosis-related network context of OTUD6A and C6ORF222 in HuRI, unfiltered (left) and filtered using colon transverse or mature eosinophil transcript levels (right).

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