Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis

The Original Article was published on 27 April 2006

Retraction to: Nature online 27 April 2006

We, the authors, are retracting this Article owing to issues that have come to our attention regarding figure assembly and data availability. Image analysis of the data has showed several image anomalies in Fig. 4c, Supplementary Figs. 1a, e and 4a. Nature has informed us that the quality and integrity of these images are not in line with journal policies. In particular, the panels affected include Supplementary Fig. 4a, which demonstrates that the shRNA construct used in the manuscript induces a reduction of LOX protein. No original data are available for the affected panels or other data included in the manuscript. We believe that the key findings of the paper are still valid as replicated by others. However, given the issues described above and the absence of original data, we have concluded that the most appropriate course of action is to retract the Article. All authors agree with the Retraction.

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Correspondence to Amato J. Giaccia.

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Erler, J.T., Bennewith, K.L., Nicolau, M. et al. Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 579, 456 (2020).

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