Extended Data Fig. 7: Indel signatures in the sample set. | Nature

Extended Data Fig. 7: Indel signatures in the sample set.

From: Tobacco smoking and somatic mutations in human bronchial epithelium

Extended Data Fig. 7

a, Five indel signatures (ID-1, ID-2, ID-3, ID-5 and ID-8) were extracted by the HDP. The contributions of different types of indels to each signature are shown, grouped by whether variants are deletions or insertions; the size of the event; whether they occur at repeat units; and the sequence content of the indel. b, Stacked bar plot showing the proportional contribution of mutational signatures to indels across the 632 colonies derived from normal bronchial cells, extracted using the HDP. Within each patient, colonies are sorted from left to right by increasing indel burden (bar chart in dark grey above coloured signature-attribution stacks).

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