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a, Primers. b, Hi-C statistics for replicate library preparations. Libraries 1 and 2 are independent preparations; 2.2 is a deeper resequencing of sample 2.1. The independent libraries 1 and 2.1 were used for Extended Data Fig. 4. A merge of replicates 1, 2.1 and 2.2 of the wild-type cells, and a merge of replicates 1, 2.1 and 2.2 of CTCFY226A/F228A mutant cells, was used for Figs. 3, 4a, Extended Data Figs. 5a, 6. c, Hi-C statistics after merging replicates of wild-type and CTCFY226A/F228A libraries.