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Worms were sorted onto NGM plates and exposed to heat-shock treatment or the indicated compounds. P values for Kaplan–Meier survival analysis were calculated on the basis of the log-rank (Mantel–Cox) method. Samples were compared with L2ox subpopulations. Maximum lifespan was defined as the lifespan of the last 10% of the population.
*Percentage change based on mean lifespan.
†Percentage change based on maximum lifespan.
‡Grx1–roGFP2 ratio of L2ox and L2red subpopulations, based on BioSorter analysis during sorting. Data are mean ± s.e.m. n, number of worms. Two-sided unpaired t-test.