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Reversion after replacement of mitochondrial DNA

Matters Arising to this article was published on 16 October 2019

The Original Article was published on 30 November 2016

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Fig. 1: Reversion to a pathogenic mutation in mtDNA, in ES cell lines derived from mitochondrial replacement embryos.
Fig. 2: Effect of CSBII haplotypes on reversion in ES cell lines after mitochondrial replacement.

Data availability

Previously unpublished4 mtDNA sequence data from ES cell lines are available online ( Additional previously published data are available from the respective publications2,3. Further supporting sequence data from ref. 3 were provided to us by one of the authors (D. Egli).


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Work in the laboratory of G.H. and M.H. is funded by Wellcome (203105/Z/16/Z). G.H. is a Newcastle University Research Fellow and receives funding from the Michael J. Fox Foundation (ID: 15643).

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G.H., Y.T. and M.H. performed the analysis. G.H. and M.H. wrote the manuscript with input from Y.T.

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Correspondence to Gavin Hudson or Mary Herbert.

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Extended data figures and tables

Extended Data Table 1 mtDNA CSBII haplotypes of nuclear and mitochondrial donors

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Hudson, G., Takeda, Y. & Herbert, M. Reversion after replacement of mitochondrial DNA. Nature 574, E8–E11 (2019).

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