Extended Data Fig. 1: Synaptic gene expression in single cell primary glioma and patient-derived xenografts. | Nature

Extended Data Fig. 1: Synaptic gene expression in single cell primary glioma and patient-derived xenografts.

From: Electrical and synaptic integration of glioma into neural circuits

Extended Data Fig. 1

a, Primary human biopsy single-cell transcriptomic data illustrating synapse associated and ion channel gene expression in H3K27M+ DMG (grey, n = 2,259 cells, 6 study participants), wild-type IDH adult high-grade glioma (red, n = 599 cells, 3 participants), IDH-mutant adult high-grade glioma (purple, n = 5,096 cells, 10 particpants) malignant cells, and tumour-associated, non-malignant immune cells (green; n = 96 cells, 5 participants) and oligodendrocytes (yellow; n = 232 cells). b, As in a for single-cell transcriptomic analysis of H3K27M+ DMG xenograft models (SU-DIPG-VI, blue; and SU-DIPG-XIII-FL, yellow) illustrating broad synaptic gene expression similar to that found in primary DMG tissue samples as shown in Fig. 1a. For each individual violin plot, the y axis represents log2(transcripts per million), and the x axis represents number of individual cells with indicated expression value.

Back to article page