Extended Data Fig. 2: Results of genome-wide CRISPRi screens for host factors crucial for CDN stimulation. | Nature

Extended Data Fig. 2: Results of genome-wide CRISPRi screens for host factors crucial for CDN stimulation.

From: SLC19A1 transports immunoreactive cyclic dinucleotides

Extended Data Fig. 2

a, b, Volcano plots of the gRNA-targeted genes enriched or depleted in the tdTomato reporter-low versus reporter-high groups after stimulation with 2′3′-RR CDA (a), or 2′3′-cGAMP (b). Each panel represents the combined results of two independent screens. Calculations of phenotypes and Mann–Whitney P values were performed as described in Methods.

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