Fig. 1: Integrated analysis of MB and cerebellar single-cell transcriptomes. | Nature

Fig. 1: Integrated analysis of MB and cerebellar single-cell transcriptomes.

From: Resolving medulloblastoma cellular architecture by single-cell genomics

Fig. 1

a, Summary of human MB and developing mouse cerebellar scRNA-seq datasets. E10, embryonic day 10; P10, postnatal day 10. b, Clinical and molecular details of the MB single-cell cohort. Asterisks indicate recurrent MB samples (n = 2/25). Samples subjected to whole-genome (G) or whole-exome (E) sequencing are indicated. c, t-distributed stochastic neighbour embedding (t-SNE) representation of the cerebellar scRNA-seq dataset. Colours represent assigned cerebellar cell types. d, Radar plot showing the CCA coefficients between each mouse cerebellar cell type (n = 18) and bulk human MB expression data3. Asterisks indicate significant correlations (FDR corrected permutation test, P < 0.05). Malig., malignant; Glu, glutamatergic; GABA, GABAergic; seq., sequencing.

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