Extended Data Fig. 2: DDGs. | Nature

Extended Data Fig. 2: DDGs.

From: Gene expression across mammalian organ development

Extended Data Fig. 2

a, Number of DDGs identified in each organ and species using the set of 7,696 1:1 orthologues (left) and the set of all protein-coding genes (right) in each species. The horizontal bar depicts the median. Br, brain; Cr, cerebellum; He, heart; Ki, kidney; Li, liver; Ov, ovary; Te, testis; Te*, testis pre-sexual maturity. b, Number of DDGs per species, including number of organs where they show dynamic expression. Asterisk denotes that ovary development is not covered in rhesus macaque, hence there are only 6 organs in total. c, Relationship between the number of organs in which genes show dynamic expression and the tolerance to functional variants as measured by: pLI score, RVIS and shet score (n = 13,160 genes; two-sided Wilcoxon rank-sum test). d, Relationship between the number of organs in which genes show dynamic expression and intolerance to duplication and deletion variants (CNV intolerance score; n = 15,728 genes; two-sided Wilcoxon rank-sum test). e, Percentage of organ-specific expressed DDGs at each developmental stage. Bars indicate the range between the replicates. For the brain tissues, DDGs are organ-specific in brain and/or cerebellum. Time points on the x axis are as described in Fig. 1a. f, Percentage of transcription factors (TFs) expressed at each developmental stage. Bars indicate the range between the replicates. Time points on the x axis are as described in Fig. 1a. Box plots are as in Fig. 3e.

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