Extended Data Fig. 6: Organ-specific stage correspondences. | Nature

Extended Data Fig. 6: Organ-specific stage correspondences.

From: Gene expression across mammalian organ development

Extended Data Fig. 6

Comparison of the global stage correspondences (based on the combined expression of somatic organs; n = 8,940 genes per organ combinations; black line) with organ-specific correspondences (based on 2,727 genes for brain, 2,146 for cerebellum, 1,276 for heart, 1,486 for kidney, 1,305 for liver, 1,298 for ovary and 2,153 for testis; coloured lines). With the exception of early heart development in opossum and early ovary development in rabbit and human, the global correspondences are within the 98% confidence interval for predictions computed by the LOESS regression function (local polynomial regression) for each of the organ-specific correspondences (shaded grey area). The same applies to all organs in mouse–chicken and mouse–rhesus macaque comparisons (data not shown). The inset on the bottom right shows the Spearman correlation between mouse and rabbit (top) and mouse and human (bottom) for testis transcriptomes using the global stage correspondences (black line) or adjusting for the different start of meiosis across species (orange line; that is, matching a P14 mouse with a young teenager in human and a P84 rabbit).

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