Extended Data Fig. 8: Structural comparison of G proteins and GPCR–G-protein complexes. | Nature

Extended Data Fig. 8: Structural comparison of G proteins and GPCR–G-protein complexes.

From: Conformational transitions of a neurotensin receptor 1–Gi1 complex

Extended Data Fig. 8

a, Overall structures of Gαi from C-state hNTSR1–Gi1 (yellow), NC-state hNTSR1–Gi1 (grey), μOR–Gi1 (green), rhodopsin–Gi1 (purple) and A1AR–Gi2 (pink) complexes. The α-helical domain of the rhodopsin–Gi1 complex is removed for clarity. b, The π–π stacking interaction between the α5 helix and β6 strand, which is specifically observed in Gi complexes. c, d, Side view and extracellular view of the superimposed structures of C-state hNTSR1–Gi1 complex (blue, hNTSR1; yellow, Gi1) and β2AR-Gs complex (grey, β2AR; orange, Gs) (c), and C-state hNTSR1–Gi1 complex (blue, hNTSR1; yellow, Gi1) and μOR–Gi1 complex (green, μOR; grey, Gi1) (d).

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