Extended Data Fig. 4: Reconstruction of terminal DNA with surrounding portal. | Nature

Extended Data Fig. 4: Reconstruction of terminal DNA with surrounding portal.

From: Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome

Extended Data Fig. 4

a, b, C1 reconstruction of terminal DNA with surrounding portal colour-zoned by pUL6 domains and tentacle helices. c, Sequence of terminal DNA mapped onto our fitted terminal DNA model. d, Enlarged view of the trailing end of terminal DNA, where concatemeric cleavage occurs. e, Enlarged view of terminal the disordered leading end of DNA, which extends down through the portal aperture towards the interior of the capsid. fh, Slab views of C1 density showing interaction of terminal DNA with tentacle helices (f), portal clip (g) and the portal aperture (h).

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