Extended Data Fig. 7: Catalytic mechanisms of CS and CCLY. | Nature

Extended Data Fig. 7: Catalytic mechanisms of CS and CCLY.

From: An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Extended Data Fig. 7

a, Catalytic mechanism of CS. The two steps of the reaction to produce citryl-CoA are labelled. An enol CoA intermediate is produced after the first step. The three arginine residues that recognize OAA are shown. The prime on the label of Arg421 indicates that it is from a different protomer of the enzyme. b, Possible catalytic mechanism of the CCLY domain of ACLY.

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