Extended Data Fig. 10: Model of the neural control of thirst and satiation. | Nature

Extended Data Fig. 10: Model of the neural control of thirst and satiation.

From: A gut-to-brain signal of fluid osmolarity controls thirst satiation

Extended Data Fig. 10

Anatomically and temporally distinct peripheral sensory signals encode information about the current hydration state of the body (blood) as well as the volume (oropharynx) and osmolarity (gastrointestinal tract) of recently ingested fluids. These signals converge on the thirst circuit of the brain to generate an integrated central representation of fluid balance at the level of individual neurons, which use this information to dynamically control drinking behaviour and vasopressin secretion in real time. Illustration from iStock/artsholic.

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